Publications
2025
Impact of spin-freezing parameters and excipient composition on product stability of a PEGylated peptide formulation
First author: Schaal
Journal Reference: Int. J. Pharm. 2025, 683, 126007.
Optimization of continuous spin-freeze-drying: The role of spin-freezing on quality attributes and drying efficiency of a model peptide formulation
First author: Schaal
Journal Reference: Eur. J. Pharm. Sci. 2025, 204, 106963.
Introduction to Spin Freeze Dryer
First author: Hori
Journal Reference: Journal of Pharmaceutical Machinery and Engineering 2025, 34, 54-61
Critical Needs and Opportunities for Advanced Manufacturing of Lyophilized Injectables
First author: Alexeenko
Journal Reference: Pharm. Res. 2025, 42, 1059–1064.
Spin freeze-drying in continuous biomanu-facturing: Boon or mirage?
First author: Ponduri
J. Drug Deliv. Sci. Technol. 2025, 116, 107909.
2024
Automated particle inspection of continuously freeze-dried products using computer vision
First author: Hervé
Journal reference: Int. J. Pharm. 2024, 664, 124629.
2023
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
First author: Meulewaeter
Journal Reference: J. Control. Release 2023, 357, 149–160.
Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process
First author: Leys
Journal Reference: Int. J. Pharm. 2023, 641, 123062.
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotec-tants and ionizable lipids
First author: Lamoot
Journal Reference: Biomater. Sci. 2023, 11, 4327-4334.
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
First author: Meulewaeter
Journal Reference: J. Control. Release 2023, 357, 149–160.
Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process
First author: Leys
Journal Reference: Int. J. Pharm. 2023, 641, 123062.
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids
First author: Lamoot
Journal Reference: Biomater. Sci. 2023, 11, 4327-4334.
2021
Innovative Drying Technologies for Biopharmaceuticals
First author: Sharma
Journal Reference: Int. J. Pharm. 2021, 609, 121115.
Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying
First author: Nuytten
Journal Reference: Pharmaceutics 2021, 13, 2076.
A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying
First author: Leys
Journal Reference: Pharmaceutics 2021, 13, 2168.
Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State
First author: Lammens
Journal Reference: Pharmaceutics 2021, 13, 2126.
Evaluation of Microwave Vacuum Drying as an Alternative to Freeze-Drying of Biologics and Vaccines: the Power of Simple Modeling to Identify a Mechanism for Faster Drying Times Achieved with Microwave
First author: Bhambhani
Journal Reference: AAPS PharmSciTech 2021, 22, 52.
2020
4D Micro-Computed X-ray Tomography as a Tool to Determine Critical Process and Product Information of Spin Freeze-Dried Unit Doses
First author: Vanbillemont
Journal Reference: Pharmaceutics 2020, 12, 430.
The Impact of Formulation Composition and Process Settings of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation
First author: Vanbillemont
Journal Reference: J. Pharm. Sci. 2020, 109, 3308-3318.
Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy
First author: Merckx
Journal Reference: JEur. J. Pharm. Biopharm. 2020, 157, 191–199.
In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
First author: Goethals
Journal Reference: Materials 2020, 13, 2953.
New Approaches to Optimize Freeze-Drying of Monoclonal Antibodies
First author: Gitter
2019
Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals
First author: Vass
Journal Reference: J. Control. Release 2019, 296, 162–178.
Achieving continuous manufacturing in lyophilization: Technologies and approaches
First author: Pisano
Journal Reference: Eur. J. Pharm. Biopharm. 2019, 142, 265–279.
Lyophilization Process Design and Development: A Single-Step Drying Approach
First author: Pansare
Journal Reference: J. Pharm. Sci. 2019, 108, 1423-1433.
Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying
First author: De Meyer
Journal Reference: Int. J. Pharm. 2019, 570, 118631.
From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses
First author: Capozzi
Journal Reference: Ind. Eng. Chem. Res. 2019, 58, 1635−1649.
2018
Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation
First author: Van Bockstal
Journal Reference: Eur. J. Pharm. Biopharm. 2018, 127, 159-170.
Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses
First author: Van Bockstal
Journal Reference: Anal. Chem. 2018, 90, 13591−13599.
The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses
First author: Lammens
Journal Reference: Int. J. Pharm. 2018, 539, 1–10.
Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying
First author: Brouckaert
Journal Reference: Anal. Chem. 2018, 90, 4354−4362.
2017
Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process
First author: Van Bockstal
Journal Reference: Eur. J. Pharm. Biopharm. 2017, 114, 11–21.
Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses
First author: De Meyer
Journal Reference: Int. J. Pharm. 2017, 532, 185–193.
2016
Noncontact Infrared-Mediated Heat Transfer During Continuous Freeze-Drying of Unit Doses
First author: Van Bockstal
Journal Reference: J. Pharm. Sci. 2017, 106, 71-82.
2015
Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses
First author: De Meyer
Journal Reference: Int. J. Pharm. 2015, 496, 75–85.