Publications

Impact of spin-freezing parameters and excipient composition on product stability of a PEGylated peptide formulation

First author: Schaal

Journal Reference: Int. J. Pharm. 2025, 683, 126007.

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Optimization of continuous spin-freeze-drying: The role of spin-freezing on quality attributes and drying efficiency of a model peptide formulation

First author: Schaal

Journal Reference: Eur. J. Pharm. Sci. 2025, 204, 106963.

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Introduction to Spin Freeze Dryer

First author: Hori

Journal Reference: Journal of Pharmaceutical Machinery and Engineering 2025, 34, 54-61

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Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

First author: Meulewaeter

Journal Reference: J. Control. Release 2023, 357, 149–160.

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Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process

First author: Leys

Journal Reference: Int. J. Pharm. 2023, 641, 123062.

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Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

First author: Lamoot

Journal Reference: Biomater. Sci. 2023, 11, 4327-4334.

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Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

First author: Meulewaeter

Journal Reference: J. Control. Release 2023, 357, 149–160.

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Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process

First author: Leys

Journal Reference: Int. J. Pharm. 2023, 641, 123062.

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Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

First author: Lamoot

Journal Reference: Biomater. Sci. 2023, 11, 4327-4334.

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Innovative Drying Technologies for Biopharmaceuticals

First author: Sharma

Journal Reference: Int. J. Pharm. 2021, 609, 121115.

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Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

First author: Nuytten

Journal Reference: Pharmaceutics 2021, 13, 2076.

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A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying

First author: Leys

Journal Reference: Pharmaceutics 2021, 13, 2168.

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Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State

First author: Lammens

Journal Reference: Pharmaceutics 2021, 13, 2126.

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Evaluation of Microwave Vacuum Drying as an Alternative to Freeze-Drying of Biologics and Vaccines: the Power of Simple Modeling to Identify a Mechanism for Faster Drying Times Achieved with Microwave

First author: Bhambhani

Journal Reference: AAPS PharmSciTech 2021, 22, 52.

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4D Micro-Computed X-ray Tomography as a Tool to Determine Critical Process and Product Information of Spin Freeze-Dried Unit Doses

First author: Vanbillemont

Journal Reference: Pharmaceutics 2020, 12, 430.

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The Impact of Formulation Composition and Process Settings of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation

First author: Vanbillemont

Journal Reference: J. Pharm. Sci. 2020, 109, 3308-3318.

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Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

First author: Merckx

Journal Reference: JEur. J. Pharm. Biopharm. 2020, 157, 191–199.

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Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals

First author: Vass

Journal Reference: J. Control. Release 2019, 296, 162–178.

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Achieving continuous manufacturing in lyophilization: Technologies and approaches

First author: Pisano

Journal Reference: Eur. J. Pharm. Biopharm. 2019, 142, 265–279.

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Lyophilization Process Design and Development: A Single-Step Drying Approach

First author: Pansare

Journal Reference: J. Pharm. Sci. 2019, 108, 1423-1433.

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Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying

First author: De Meyer

Journal Reference: Int. J. Pharm. 2019, 570, 118631.

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From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses

First author: Capozzi

Journal Reference: Ind. Eng. Chem. Res. 2019, 58, 1635−1649.

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Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

First author: Van Bockstal

Journal Reference: Eur. J. Pharm. Biopharm. 2018, 127, 159-170.

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Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses

First author: Van Bockstal

Journal Reference: Anal. Chem. 2018, 90, 13591−13599.

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The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

First author: Lammens

Journal Reference: Int. J. Pharm. 2018, 539, 1–10.

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Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process

First author: Van Bockstal

Journal Reference: Eur. J. Pharm. Biopharm. 2017, 114, 11–21.

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Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses

First author: De Meyer

Journal Reference: Int. J. Pharm. 2017, 532, 185–193.

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Publications

2025

Impact of spin-freezing parameters and excipient composition on product stability of a PEGylated peptide formulation

Optimization of continuous spin-freeze-drying: The role of spin-freezing on quality attributes and drying efficiency of a model peptide formulation

Introduction to Spin Freeze Dryer

Critical Needs and Opportunities for Advanced Manufacturing of Lyophilized Injectables

2024

Automated particle inspection of continuously freeze-dried products using computer vision

2023

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

2021

Innovative Drying Technologies for Biopharmaceuticals

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying

Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State

Evaluation of Microwave Vacuum Drying as an Alternative to Freeze-Drying of Biologics and Vaccines: the Power of Simple Modeling to Identify a Mechanism for Faster Drying Times Achieved with Microwave

2020

4D Micro-Computed X-ray Tomography as a Tool to Determine Critical Process and Product Information of Spin Freeze-Dried Unit Doses

The Impact of Formulation Composition and Process Settings of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions

New Approaches to Optimize Freeze-Drying of Monoclonal Antibodies

2019

Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals

Achieving continuous manufacturing in lyophilization: Technologies and approaches

Lyophilization Process Design and Development: A Single-Step Drying Approach

Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying

From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses

2018

Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

2017

Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses

2016

Noncontact Infrared-Mediated Heat Transfer During Continuous Freeze-Drying of Unit Doses

2015

Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses