--- title: References --- ![team-hr-employers-preparing-interview-questions-vet-selected-applicants](https://www.rheavita.com/hs-fs/hubfs/Not%20used/team-hr-employers-preparing-interview-questions-vet-selected-applicants.jpg?height=2000&name=team-hr-employers-preparing-interview-questions-vet-selected-applicants.jpg) Client Testimonies # References ![sanofi-logo](https://www.rheavita.com/hs-fs/hubfs/sanofi-logo.png?width=351&height=165&name=sanofi-logo.png) ![pfizer-logo](https://www.rheavita.com/hs-fs/hubfs/pfizer-logo.png?width=113&height=47&name=pfizer-logo.png) ![bayer-logo](https://www.rheavita.com/hs-fs/hubfs/bayer-logo.png?width=351&height=351&name=bayer-logo.png) ![gsk-logo](https://www.rheavita.com/hs-fs/hubfs/gsk-logo.png?width=409&height=351&name=gsk-logo.png) ![coriolis-logo](https://www.rheavita.com/hs-fs/hubfs/coriolis-logo.jpg?width=351&height=186&name=coriolis-logo.jpg) ![patheon_logo](https://www.rheavita.com/hs-fs/hubfs/patheon_logo.jpeg?width=200&height=200&name=patheon_logo.jpeg) ![logo_UGent_EN_RGB_2400_color](https://www.rheavita.com/hs-fs/hubfs/logo_UGent_EN_RGB_2400_color.png?width=3543&height=2835&name=logo_UGent_EN_RGB_2400_color.png) ![astellas-logo-1](https://www.rheavita.com/hs-fs/hubfs/astellas-logo-1.jpeg?width=1280&height=352&name=astellas-logo-1.jpeg) ## Astellas: Faster Processing, Easier Inspection, Better Usability **The Challenge:** Conventional batch lyophilization is time-consuming and can make foreign matter detection difficult while requiring lengthy reconstitution times for healthcare professionals. **The Solution:** **Astellas** demonstrated that **RheaLyo™ Spin Freeze-Drying **maintained product stability while reducing processing time by **97%**, shortening reconstitution time by up to **85%**, and improving the detectability of foreign particles. Resources: [**Yoshikata M., Ito H., Nagata J., Kawatsu S.** *Feasibility Study for Continuous Freeze-drying.* Poster presented at the **PBP World Meeting 2026**, Astellas Pharma Inc., Yaizu, Japan.](https://www.rheavita.com/hubfs/2026%20-%20Yoshikata%20-%20PBP%20World%20Meeting%20-%20Abstract.pdf?hsLang=en)     ![astellas-office](https://www.rheavita.com/hs-fs/hubfs/astellas-office.jpg?width=700&height=466&name=astellas-office.jpg) ## Thermo Fisher (Patheon): Reducing Lyophilization from 7 Days to 3 Hours **The Challenge:** Conventional batch lyophilization of complex formulations can require up to seven days, delaying development timelines, increasing manufacturing costs, and exposing sensitive drug products to prolonged process stress. **The Solution:** RheaLyo™ Spin Freeze-Drying reduced the lyophilization cycle from **7 days to just 3 hours**—a **98% reduction**—while maintaining product quality and improving critical quality attributes, paving the way for accelerated development of complex formulations. Resources: [**Turdo E., Selis F., Iaconelli E., Lammens J., De Beer T., Salzano G.**  Poster presented at the **PDA Italy Chapter Meeting**. Thermo Fisher Scientific (Monza, Italy) & RheaVita (Ghent, Belgium).](https://www.rheavita.com/hubfs/Turdo_E._et_al_PDA_Italy_Chapter-1.pdf?hsLang=en)     ![Monza](https://www.rheavita.com/hs-fs/hubfs/Monza.jpg?width=1800&height=1020&name=Monza.jpg) ## Sanofi mRNA LNP Drug Product Continuous Manufacturing The Challenge: The shift towards continuous bioprocessing presents a transformative opportunity for LNP manufacturing. However, equipment engineering and automation need to be adapted. The Solution: A combination of DIANT® Jet technology for nanoparticle production and RheaLyo™ Spin Freeze-Drying technology. Resources: [Presentation by F. Peral, GMP Researcher, Sanofi, Waltham (MA) at the 9th Annual CCP Summit.](https://www.rheavita.com/hubfs/CMC%20Presentation%20-%209th%20Annual%20CCP%20Sumit%20Feb26th%202025%20-%20F.PERAL%20VF.pdf?hsLang=en)   ![mRNA_LNP_3](https://www.rheavita.com/hs-fs/hubfs/emails/mRNA_LNP_3.jpg?width=2000&name=mRNA_LNP_3.jpg) ## Pfizer Single Vial Unit Experience Experimental work on LNP, AAV and protein formulations. Resources: [Presentation by Jacob Hamilton, James Searles (Pfizer) at IFPAC conference.](https://www.rheavita.com/hubfs/Hamilton_IFPAC%202023_PDF.pdf?hsLang=en) ![floating-image1-1](https://www.rheavita.com/hs-fs/hubfs/RheaVita-BV%20Images/Images/floating-image1-1.png?width=720&height=480&name=floating-image1-1.png) ## Bayer Spin-freezing Parameter Study This study examines the impact of spin‑freezing parameters on formulation composition and stability of a PEGylated peptide. Formulation composition and storage temperature, rather than spin-freezing conditions, drive long-term stability. Resources: [Schneider, Oral presentation at Garmisch-Partenkirchen Lyo conference 2025.](https://www.rheavita.com/hubfs/Schneid_Lyo_Garmisch_2025.pdf?hsLang=en) [Schaal et al., International Journal of Pharmaceutics Volume 683, 15 October 2025, 126007](https://doi.org/10.1016/j.ijpharm.2025.126007) ![Bayer-Schneid](https://www.rheavita.com/hs-fs/hubfs/Bayer-Schneid.png?width=2000&name=Bayer-Schneid.png) ## GSK Spin-freeze-drying of a live attenuated viral vaccine The huge reduction in freeze-drying time (3 hours as opposed to 47 hours in the traditional batch procedure) is a striking benefit of continuous spin-freeze-drying. Temperature stress tests demonstrate that continuous spin-freeze-drying is a reliable alternative to the traditional batch freeze-drying process to preserve the long-term stability of viral vaccines. Resources: [Poster CESPE conference 2023](https://www.rheavita.com/hubfs/Laleman-CESPE-2023-Poster.pdf?hsLang=en) ![Human viruses (EM)](https://www.rheavita.com/hs-fs/hubfs/AI-Generated%20Media/Images/electron%20microscope%20view%20of%20human%20virus.jpeg?width=1344&height=768&name=electron%20microscope%20view%20of%20human%20virus.jpeg) ## Coriolis Pharma offers the RheaVita technology to its clients [Coriolis Pharma](https://www.coriolis-pharma.com) extends its service portfolio by integrating RheaVita’s Single Vial unit (SVU) technology for continuous and controlled freeze-drying to stabilize novel modalities as part of biologics drug product development for clients. Resources: [Oral presentation by Maitê Harguindeguy, Scientist, “Advanced Freeze-Drying Technologies for Drug Product Development”, at The Pharma days Geneva 2025.](https://www.rheavita.com/hubfs/20250430_The_Phama_Days_2025_Coriolis_RheaVita_V01_final_MHa.pdf?hsLang=en) ![Coriolis-badge](https://www.rheavita.com/hs-fs/hubfs/Coriolis-badge.png?width=841&height=595&name=Coriolis-badge.png) ## Latest news ![](https://www.rheavita.com/hubfs/Bayer-wuppertal-1.jpeg) Industry brief #### What a Bayer Case Study Reveals About Continuous Freeze-Drying of Peptide Drug Products Read ![](https://www.rheavita.com/hubfs/AI-Generated%20Media/Images/The%20image%20depicts%20an%20empty%20glass%20vial%20as%20used%20for%20pharmaceutical%20products%20standing%20on%20a%20pile%20of%20books%20The%20books%20are%20guidelines%20for%20manufaturers%20An%20example%20is%20Annex%201-1.png) Industry brief #### Embracing Annex 1 Compliance with Advanced Freeze-Drying Read ![](https://www.rheavita.com/hubfs/Monza.jpg) News #### Patheon (Thermo Fisher Scientific) brings RheaVita’s continuous and controlled lyophilization technology to Monza site Read ![](https://www.rheavita.com/hubfs/Stoppered-1.png) News #### Top Pharmaceutical Freeze Drying Solution in Europe Read ![](https://www.rheavita.com/hubfs/Not%20used/GMP%20Flex_%20Spin-Stopper%20Isolator%20(RH)-1.png) Industry brief #### Accelerating Biopharma R&D with Continuous Freeze-Drying Read ![](https://www.rheavita.com/hubfs/site/website-pages/vial-with-jet-and%20red-beam_LinkedIn-optimized.jpg) Industry brief #### Innovative Spin-Freeze-Drying Technology Read ![](https://www.rheavita.com/hubfs/GMP%20Flex_%20Spin-Stopper%20Isolator%20(RH)-2.png) Industry brief #### Reimagining Batch Freeze-Drying: Scientific Solutions for Persistent Pain Points Read ![](https://www.rheavita.com/hubfs/AI-Generated%20Media/Images/The%20image%20features%20a%20stateoftheart%20BSL2%20laboratory-1.jpeg) News #### Launch of the BSL-2 compliant laboratory freeze-dryer Read ![](https://www.rheavita.com/hubfs/frost-window.jpg) News #### RheaVita joins lyoHUB Read ![](https://www.rheavita.com/hubfs/Generated%20Blog%20Post%20Images/Pharmaceutical%20manufacturing%20equipment%20showcasing.jpeg) Industry brief #### The Importance of Continuous Manufacturing Systems in Pharma Read Read more #### Stay in the know. 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